WP4324 - Mitochondrial complex I assembly model OXPHOS system - Homo sapiens
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This pathway shows how all 45 different subunits are assembled into complex 1 (relevant for the electron transport chain, also known as OXPHOS system), which chaperones (visualized with a small circle and a "C') and which post-translational modifications (a dimethylation on NDUFS2 and hydroxylation on NDUFS7, both in the Q-module) are needed for this assembly.
Most of the steps involved in this intricate process have been described in separate literature references, which have been combined in a [review by Alba Signes and Erika Fernandez-Vizarra](https://doi.org/10.1042/EBC20170098). If possible (based on the size of the protein in KD and available protein structures in Uniprot), the color of the protein structure drawings have been matched to the annotated protein DataNodes.
Abbreviations: IM, inner membrane; IMS, intermembrane space.
创建时间：
2025-04-17
