CCL17

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

该抗菌基因是位于第16号染色体q臂上的一组多个Cys-Cys（CC）细胞因子基因之一。细胞因子是一类参与免疫调节和炎症过程的分泌蛋白。CC细胞因子是一类具有两个相邻半胱氨酸的蛋白质。该基因编码的细胞因子对T淋巴细胞具有趋化活性，而对单核细胞或粒细胞则不具有。该基因产物与趋化因子受体CCR4和CCR8结合。该趋化因子在胸腺中T细胞发育以及成熟T细胞的迁移和激活过程中发挥着重要作用。[由RefSeq提供，2014年9月]