Organocatalyzed Enantioselective Direct Mannich Reaction of α‑Styrylacetates
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https://figshare.com/articles/dataset/Organocatalyzed_Enantioselective_Direct_Mannich_Reaction_of_Styrylacetates/3394291
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资源简介：
An organocatalyzed
direct Mannich reaction of unactivated α-styrylacetates
was realized for the first time. By using a quinidine-derived C6′-urea
catalyst, the direct Mannich reaction of α-styrylacetates and N-tosylimines gave the desired β-amino esters in high
yields, diastereoselectivities, and ee values. The reaction provides
a highly stereoselective (up to 96:4 dr and 97% ee) and the most straightforward
synthesis of functionalized N-tosylated β-amino
esters. The products can be used as precursors for the highly selective
synthesis of tetrahydrofuran derivatives.
创建时间：
2016-05-27
