Blood based expression of colorectal cancer and healthy controls

The immune system is crucial in regulating colorectal cancer tumorigenesis. Identification of immune-related transcriptomic signatures derived from the peripheral blood of colorectal cancer patients will provide insights into colorectal cancer pathogenesis and suggest novel clues to potential colorectal cancer immunotherapy strategies. We used microarrays to detail the blood-based gene expression of colorectal cancer patients and healthy controls to identify the colorectal cancer-specific immune genes potentially diagnostic for colorectal cancer. We collected blood samples from 59 colorectal cancer patients and 62 healthy controls and carried out whole blood gene expression profiling using affymetrix microarray hybridization. Immune-related gene expression signatures for colorectal cancer were identified from immune gene datasets, and an algorithmic predictive model was constructed for distinguishing colorectal cancer from controls.