Additional file 2 of Biological and therapeutic implications of sex hormone-related gene clustering in testicular cancer

Supplementary Material 2: Furthermore,“Supplementary Material” is as a PDF file also available with a detailed description of the Methods ( Software; Data sources; Descriptive statistics, significance and effect size; Differential expression of sex hormone-related genes in histologies of testicular cancers; Co-regulation networks of sex hormone-related genes; Clustering of testicular cancer samples in respect to sex hormone-related gene expression; Demographic, clinical, pathological, and prognostic characteristic of the clusters; Tumor microenvironment of the hormonal clusters; Gene set variation analysis for Reactome pathway gene signatures; Differential gene and protein expression, and differences in predicted drug sensitivity; Protein co-regulation networks; GO enrichment analysis and semantic clustering of GO terms; Transcriptional regulons and signaling; Metabolic reaction and metabolic subsystem activity; Genetics of the hormonal clusters; Data and code availability). Supplementary Tables and Supplementary Figures regarding detailed results of our analysis are involved, as well.