Expression modes and tagging systems for AP/MS screening.

The Arifuzzaman dataset is an outlier when compared with other AP/MS datasets. A possible explanation is that it is the only screen that combined both non-physiological protein expression and His-tagging instead of the superior tandem purification procedure. Note: by default AP/MS datasets are interpreted using the spoke model. In addition we list the Gavin network derived by socio-affinity scoring (scores above ). The Collins dataset relies on the same experimental data as the Krogan and Gavin datasets and is derived by a method similar to socio-affinity [7].