Porcine Colitis Recapitulates Adipose Immuno-Metabolic Reprogramming in Human Ulcerative Colitis

Here, we employed a dextran sulfate sodium (DSS)-induced porcine colitis model to: (1) delineate the inherent transcriptomic signatures of porcine mAT and inguinal adipose tissue (iAT) under physiological homeostasis; (2) dissect the coordinated and depot-specific responses of these tissues in transcription, immunity, and lipolytic remodeling under colitis conditions; and (3) validate, through cross-species comparisons, the superiority of the porcine model over murine models in recapitulating human UC pathology, particularly its metabolic suppression features. This study, leveraging a large animal model, systematically elucidates the depot-specific transcriptomic and immunologic responses of visceral and subcutaneous fat depots to intestinal inflammation, providing foundational insights for translational medicine in IBD and porcine enteritis research.