Engineering IgG1 Fc specificity and affinity for Fc gamma receptors using deep mutational scanning titrations
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下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1089143
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资源简介：
We made barcoded libraries of IgG1 Fc, each containing ~4,350 distinct single amino acid mutations. We then applied deep mutational scanning technology to quantify IgG1 Fc mutational impact on specificity and affinity for various Fc gamma receptors. We used a lentiviral system for expression of IgG1(216-447) on the surface of mammalian HEK293T cells.
创建时间：
2024-03-18
