Genotype-phenotype-analysis of SNP rs6887695 in patients with Crohn's disease (CD).

PCC:P-value for testing for differences between homozygous carriers of the C allele (C/C) and heterozygous and non-carriers of the C allele. ORCC: corresponding odds ratios and 95% confidence intervals (95% CI). Significant P-values (<0.05) are depicted in bold, P-values showing a trend towards significance are depicted in Italic fonts. P-values marked with an asterisk * remained significant after Bonferroni correction.
1Disease behaviour was defined according to the Montreal classification. A stricturing disease phenotype was defined as presence of stenosis without penetrating disease. The diagnosis of stenosis was made surgically, endoscopically, or radiologically (using MRI enteroclysis).
2Immunosuppressive agents included azathioprine, 6-mercaptopurine, 6-thioguanin, methotrexate, infliximab and/or adalimumab.
3Only surgery related to CD-specific problems (e.g. fistulectomy, colectomy, ileostomy) was included.