Visible Light-Induced Three-Component Alkoxyalkylation of Alkenes with α‑Halocarbonyls and Alcohols

A visible-light-induced three-component
alkoxyalkylation
of alkenes
has been developed under the photocatalysis of fac-Ir(ppy)3. The alkene substrate scope included aryl and
aliphatic alkenes as well as electron-rich and electron-deficient
alkenes, allowing the facile coupling with a diverse array of α-halocarbonyl
compounds. The redox potential-guided orchestration of radical processes
with precision allows rapid access to highly functionalized products
that are useful building blocks in organic synthesis.