Human Protein Atlas - Disease

The Human Disease Blood Atlas contains information on protein levels in blood in patients with different diseases and highlights proteins associated with these diseases using differential expression analysis and a disease prediction strategy based on machine-learning. In this version, a pan-cancer study is reported covering 1463 proteins quantified by Proximity Extension Assay (PEA) and 146 proteins quantified by isotope dilution strategies based on the addition of recombinant protein fragment standards – the gold standard of quantitative mass spectrometry. Protein profiles have been quantified across 12 major cancer types. More information about the specific content and the generation and analysis of the data in the section can be found in the Methods Summary.
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comprehensive and precise protein levels in blood covering 12 different cancer types
proteins associated with each of the analyzed cancers

《人类疾病血液图谱》收录了不同疾病患者血液中蛋白质水平的信息，并利用差异表达分析和基于机器学习的疾病预测策略，突出了与这些疾病相关的蛋白质。在本版中，报告了一项涵盖1463种蛋白质的泛癌研究，这些蛋白质通过邻近延伸测定法（PEA）进行量化，以及146种蛋白质通过基于添加重组蛋白片段标准品的同位素稀释策略进行量化——这是定量质谱学的黄金标准。蛋白质谱已对12种主要癌症类型进行量化。关于具体内容以及数据的生成和分析的更多信息，可在方法概要部分查阅。了解涵盖12种不同癌症类型的全面且精确的血液蛋白质水平，以及与每种分析癌症相关的蛋白质。