Expression data from Plasmodium falciparum

Artemisinin and its derivatives exert the potent, antimalarial action, although the mechanisms by which these drugs inhibit the growth of mararia parasites is not fully understood. We used microarrays to detail the global gene expression change in early erythrocytic P. falciparum, and identified molecules that may contribute to the activity of dihydroartemisinin. To identify genes differentially expressed in P. falciparum exposed to dihydroartemisinin other drugs 7-benzylidenealtrexone and rimonaband were also analyzed.