Angiotensin-converting enzyme 2 G8790A polymorphism are associated with COVID-19 severity: a meta-analysis and bioinformatics analysis

In order to prevent COVID-19 from progressing, angiotensin-converting enzyme 2 (ACE2) binds to SARS-CoV-2 and prevents the virus from entering target cells. Several studies have found a correlation between COVID-19 risk and the ACE2 G8790A polymorphism; nevertheless, the conclusion remains inconclusive.To more accurately estimate the risk of COVID-19, a meta-analysis with relevant articles was carried out.