Viral escape from an intricate HIV-Gag specific CTL response restricted by three HLA-alleles followed in patient OP428.

AEstimated weeks from infection. BThe Consensus B sequence is given as a reference for amino acid position 71 to 101 of the HIV-1 Gag p17 region. The HLA-A2 restricted epitope SL9 is underlined with a single unbroken line, the HLA-A1 restricted epitope GY9 with a dotted line, and the HLA-B8 restricted epitope EL9 with double lines. CThe frequency of each clone is given as a number of the total number of clones sequenced. The major autologous sequence at each time-point is given in bold face letters. DThe autologous CTL responses are given for each peptide tested. The at week 63 minor viral sequence, which by week 139 becomes the major viral sequence, are indicated by a black box. Likewise, the corresponding CTL responses are surrounded by black boxes for each of the HLA-A2-, HLA-A1-, and HLA-B8-restriced responses, respectively. The viral variant that generates the strongest CD8+ T cell response for every HLA-restriction at each time-point is given in bold.