Supporting data for “Sleep Dysfunction, Cerebral Small Vessel Disease Burden and Cognitive Impairment in Patients with Stroke"

Stroke is the second leading cause of death and a major cause of disability worldwide. Sleep dysfunction, including obstructive sleep apnea (OSA) and poor sleep quality, are prevalent but often neglected in stroke patients. Although it is estimated that over 70% of stoke patients suffer from OSA, and up to 40% experience insomnia following stroke, only around 6% are offered an official sleep test. Cerebral small vessel disease (CSVD) and cognitive impairment are commonly encountered in stroke patients. CSVD contributes to 25% of stroke and 45% of dementia globally; while up to 50% of stroke patients experience neurocognitive disorders. To date, little is known about the determinants of high OSA prevalence in the stroke population, and the relationship of sleep dysfunction with CSVD burden or cognitive impairment following stroke.

The studies described in my PhD thesis have four key aims: 1) to systematically assess the prevalence and determinants of OSA in stroke population; 2) to explore the association of OSA status with CSVD burden in stroke patients; 3) to investigate the association of sleep quality with CSVD burden in stroke patients; and 4) to evaluate the impact of sleep disturbances on the longitudinal cognitive trajectory following stroke.

I prospectively recruited patients with newly diagnosed transient ischemic attack (TIA) or minor stroke (National Institute of Health Stroke Scale

中风是全球第二大死因，也是导致残疾的主要原因。睡眠功能障碍，包括阻塞性睡眠呼吸暂停（OSA）和睡眠质量低下，在中风患者中普遍存在，但往往被忽视。尽管估计超过70%的中风患者患有OSA，高达40%的患者在中风后经历失眠，但仅有约6%的患者接受了官方的睡眠测试。脑小血管病（CSVD）和认知障碍在中风患者中常见。CSVD是全球25%的中风和45%的痴呆症的诱因；而高达50%的中风患者经历神经认知障碍。迄今为止，关于中风人群中高OSA发病率的决定因素以及睡眠功能障碍与中风后CSVD负担或认知障碍之间的关系，知之甚少。

我所描述的博士论文中的研究具有四个关键目标：1）系统地评估中风患者中OSA的患病率和决定因素；2）探讨OSA状态与中风患者CSVD负担之间的关联；3）研究睡眠质量与中风患者CSVD负担之间的关联；4）评估睡眠障碍对中风后纵向认知轨迹的影响。

我前瞻性地招募了患有新诊断的短暂性脑缺血发作（TIA）或轻微中风（美国国立卫生研究院中风量表）的患者。