Possible activating mutations found in cancer sequencing projects.

*Tissue refers to the cancer tissue that this particular mutation was found in. Colorectal and breast are from Wood et al. [14], Pancreatic is from Jones et al. [11], GBM refers to glioblastoma data from Parsons et al. [12], CGA_GBM is glioblastoma data from The Cancer Genome Atlas publication [8], and lung refers to lung adenocarcinoma data from Ding et al. [9].
+in the Tissue column denotes that this gene is significantly overexpressed in cancer (p<0.01, t-test), compared to normal samples of the same tissue type (Gene Logic expression data, see Methods).