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Identification of candidate genes and pathways in dexmedetomidine-induced cardioprotection in the rat heart by bioinformatics analysis [miRNA]

Alliance of Genome Resources2026-08-01 收录

药物心脏保护

miRNA-mRNA差异表达分析

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https://www.ncbi.nlm.nih.gov/gds/?term=GSE126105 数据链接链接失效反馈

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Differentially expressed miRNAs and mRNAs after dexmedetomidine administration in rat hearts were successfully identified by conducting microarray analysis.

应用场景：

肠道菌群分析

药物心脏保护

To demonstrated demonstrated whether glabridin protects against DOX-induced cardiotoxicity in mice through prevention of gut microbiota dysbiosis, we test the 16s rRNA of gut microbiota in mice.

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Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

药物心脏保护

拓扑异构酶抑制剂优化

Cardioprotective activity of dexrazoxane (ICRF-187), the only clinically approved drug against anthracycline-induced cardiotoxicity, has traditionally been attributed to its iron-chelating metabolite.

NIAID Data Ecosystem40

Table1_Synergistic cardioprotective effects of melatonin and deferoxamine through the improvement of ferritinophagy in doxorubicin-induced acute cardiotoxicity.DOCX

药物心脏保护

铁蛋白自噬

Ferritinophagy is one of the most recent molecular mechanisms affecting cardiac function. In addition, it is one of the pathways by which doxorubicin, one of the anticancer drugs commonly used, negati

NIAID Data Ecosystem20

Identification of differentially expressed miRNAs and mRNAs in synovial tissues of osteoarthritis via RNA-sequencing

骨关节炎滑膜组织转录组

miRNA-mRNA差异表达分析

Background: Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability. This study attempted to investigate the key mRNAs and miRNAs related to OA. Patients and methods

NIAID Data Ecosystem60

SFN administered during DOX-treatment improves ETC function in non-tumor bearing animals.

药物心脏保护

线粒体呼吸功能评估

Respiration status of complex I, II+III, and IV of the ETC was evaluated in fresh left ventricular tissue as described in the Materials and Methods. According to oxygen flux measures (pmol/mg/substrat

Figshare2018-03-09 更新30

Identification of candidate genes and pathways in dexmedetomidine-induced cardioprotection in the rat heart by bioinformatics analysis [miRNA]

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