eccDNAdb

eccDNAdb currently includes 1270 eccDNAs, which were identified in 480 samples (of 42 cancers) after analyzing a total number of 3395 tumor samples (of 57 cancers) including patient tissues, patient-derived xenografts, and cancer cell lines. A total number of 54,901 eccDNA genes were annotated and included in the database as well. With the integration of gene expression, clinical information and chromatin accessibility data, eccDNAdb enables users to easily determine the biological function and clinical relevance of eccDNAs in human cancers.

eccDNAdb目前收录了1270条环状染色体外DNA（extrachromosomal circular DNA，eccDNA），这些eccDNA是在对涵盖57种癌症的3395份肿瘤样本进行分析后，从其中42种癌症的480份样本中鉴定得到的。本次分析的肿瘤样本涵盖患者组织、患者来源异种移植瘤以及癌细胞系。该数据库同时注释并收录了总计54,901个eccDNA相关基因。通过整合基因表达、临床信息与染色质可及性数据，eccDNAdb可帮助用户便捷地探究人类癌症中eccDNA的生物学功能与临床相关性。

搜集汇总

背景与挑战

背景概述

eccDNAdb是一个包含1270个eccDNAs和54,901个相关基因注释的数据库，这些数据源自对3395个肿瘤样本的分析，覆盖多种癌症类型。通过整合基因表达、临床信息和染色质可及性数据，该数据库支持用户探索eccDNAs在人类癌症中的生物学功能与临床意义。