Mammalian Methylation Consortium

The Mammalian Methylation Consortium aimed to characterize the relationship between cytosine methylation levels and a) species characteristics such as maximum lifespan and b) individual sample characteristics such as age, sex, tissue type. Both supervised machine learning approaches and unsupervised machine learning approaches were applied to the data as described in the citations. To facilitate comparative analyses across species, the mammalian methylation consortium applied a single measurement platform (the mammalian methylation array, GPL28271) to n=15216 DNA samples derived from 70 tissue types of 348 different mammalian species (331 eutherian-, 15 marsupial-, and 2 monotreme species). Most of the CpGs are located in highly conserved stretches of DNA but not all CpGs apply to all species as detailed in the description of the platform, GPL28271 and on https://github.com/shorvath/MammalianMethylationConsortium/.哺乳动物甲基化联盟（Mammalian Methylation Consortium）旨在阐明胞嘧啶甲基化水平与两类特征的关联：一类为物种层面特征（如最大寿命），另一类为个体样本层面特征（如年龄、性别、组织类型）。本数据集按照引用文献中描述的方法，同时采用了监督式机器学习与非监督式机器学习两类分析手段对数据进行处理。为支持跨物种比较分析，该联盟采用统一的检测平台——哺乳动物甲基化芯片（GPL28271），对来自348种不同哺乳动物（含331种真兽类、15种有袋类及2种单孔类）的70种组织类型的15216份DNA样本开展了检测。绝大多数CpG位点（CpG）位于高度保守的DNA区段内，但并非所有CpG位点均适用于所有物种，相关细节可查阅该检测平台GPL28271的说明文档，以及https://github.com/shorvath/MammalianMethylationConsortium/ 网站内容。