RNA-seq of muscles from young and aged ATF4 mKO mice and littermate controls

To investigate the roles of ATF4 in skeletal muscle aging we generated muscle-specific ATF4 knockout (ATF4 mKO) mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of tibialis anterior muscles at 6-months and 22-months of age. Tibialis anterior mRNA profiles of 6-month-old and 22-month-old ATF4 mKO and control mice为探究活化转录因子4（ATF4）在骨骼肌衰老过程中的作用，本研究构建了肌肉特异性ATF4敲除（ATF4 mKO）小鼠模型。随后，我们针对6月龄与22月龄小鼠的胫骨前肌（tibialis anterior）开展RNA测序（RNA-seq），并基于所得数据进行基因表达谱分析。本数据集包含6月龄及22月龄ATF4 mKO小鼠与对照小鼠的胫骨前肌mRNA表达谱数据。