Study of sarcopenia in human muscle biopsies of elderly individuals, Hertfordshire Sarcopenia Study

Purpose: The main goal of this study is to compare skeletal muscle transcriptome profilings derived from sarcopenic versus healthy subjects. Methods: We use high coverage RNA sequencing of human skeletal muscle biopsies to analyze genome-wide transcriptional changes in human sarcopenia benchmarked to healthy elderly controls. 28 muscle biopsies from healthy subjects, 4 muscle biopsies from sarcopenic subjects, 5 muscle biopsies from subjects with only low muscle mass, 3 muscle biopsies from subjects with only low muscle strength or low muscle function.