BAF60a governs β-cell identity to control systemic glucose homeostasis

In this study, we employed multiple sequencing techniques to investigate the role of BAF60a in maintaining systemic glucose homeostasis. This dataset comprises processed RNA-Seq, scRNA-Seq, and ATAC-Seq data from islets of flox/flox and β-cell specific BAF60a knockout (BaBKO) mice, revealing alterations in chromatin configuration, transcriptional networks, cell identity, and cellular metabolism resulting from BAF60a loss-of-function. Additionally, we provide a CUT&Tag-Seq dataset showing BAF60a binding sites on chromatin in chow and high-fat diet (HFD) fed mouse islets, along with the BAF60a interactome study shown in the manuscript. Detailed procedures for sample collection and data analysis are included in the Experimental Section of the manuscript.