Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Chronic activation of Notch1 synergizes with multiple oncogenic pathways altered in early prostate cancer to promote the development of prostate adenocarcinoma. Expression profiling revealed that these tumors display features of epithelial-to-mesenchymal transition, a cellular state associated with increased tumor aggressiveness.Tumors driven by Notch1 intracellular domain in combination with multiple pathways altered in prostate cancer are metastatic and resistant to androgen deprivation.
提供机构：
Stanford University
创建时间：
2022-02-20
