"Susceptibility of brain atrophy to TRIB3 in Alzheimer’s disease: evidence from functional prioritization in imaging-genetics": Experimental material

This collection provides the experimental material associated to the publication "Susceptibility of brain atrophy to TRIB3 in Alzheimer’s disease: evidence from functional prioritization in imaging genetics", accepted for publication in the Proceedings of the National Academy of Sciences of the United States of America (PNAS).It contains 4 items:<br>- SNP_list_position.csv<br>This .csv file provides the list of SNPs analyzed in the work with associated chromosome and position.<br>- Selection_Probabilities.npyThis is a numpy list generated with Python2.7.Each element of the list is associated to a PLS component. Each element is a list of 22 arrays, one per chromosome. Each array reports the selection probability associated to each genetic bin. The position (start-end) of each bin is reported in the file SNP_range.npy.<br>- SNP_range.npyThis is a numpy list generated with Python2.7.<br>The list contains 22 arrays associated to each chromosome. Each element of the array is a position for the genetic bins used in the analysis.<br>- genetic_component.npyThis is a numpy list generated with Python2.7.It contains the 3 genetic components estimated through partial least squares. The dimension of each component is 1167117, corresponding to the number of SNPs analyzed in the study and listed in the file SNP_list_position.csv.<br> <br><br><br><br><br>