Additional file 4. A retroviral shRNA library used to screen for genes involved in the maintenance of X inactivation. The genes targeted and the numbers of hairpins against each are shown. Dnmt1 [66,6
A long form (tRNase ZL) of tRNA 3′ processing endoribonuclease (tRNase Z, or 3′ tRNase) can cleave any target RNA at any desired site under the direction of artificial small guide RNA (sgRNA) that mim
Xist RNA, the master regulator of X chromosome inactivation, acts in cis to induce chromosome silencing through the stepwise recruitment of factors that modify underlying chromatin structure. Whilst
