Essential functions of the Glucocorticoid Receptor require direct DNA binding [RNA-seq]. Essential functions of the Glucocorticoid Receptor require direct DNA binding [RNA-seq]

We performed RNA sequencing in Mouse Embryonic Fibroblasts (MEFs) of GR wild-type and GR Zn. Cells were treated with: vehicle (EtOH), Dexamethasone (Dex), Lipopolysaccharide (LPS) or Dex+LPS. We show that GR Zn does not regulate any GR target gene Overall design: mRNA profile of GR wild-type and GR Zn MEFs treated with vehicle, Dex, LPS or DexLPS