A Zn(II)-based coordination polymer: reduced the nicotinic acetylcholine receptors levels and exerted analgesic activity after total knee arthroplasty

Based on the mixed ligands p-terphenyl-2,2′′,5′′,5′′′-tetracarboxylate acid (H4tptc) and 1,10-phenanthroline (phen), a new coordination polymer with the chemical formula of [Zn(tptc)0.5(phen)]n(1) constructed under solvothermal conditions and further characterized via the single crystal X-ray diffraction, powder X-ray diffraction, elemental analysis, Fourier transform infrared spectra (FTIR), and thermogravimetric analysis (TGA). Its analgesic activity was evaluated on rat model. In addition to this, the RT-PCR was further performed for the determination of the nicotinic acetylcholine receptors on presynaptic membrane.