Data from:A computational study of cancer hyperthermia based on vascular magnetic nanoconstructs

The application of hyperthermia to cancer treatment is studied using a
novel model arising from the fundamental principles of flow, mass and heat
transport in biological tissues. The model is defined at the scale of the
tumour microenvironment and an advanced computational scheme called the
embedded multiscale method is adopted to solve the governing equations.
More precisely, this approach involves modelling capillaries as
one-dimensional channels carrying flow, and special mathematical operators
are used to model their interaction with the surrounding tissue. The
proposed computational scheme is used to analyse hyperthermic treatment of
cancer based on systemically injected vascular magnetic nanoconstructs
carrying super-paramagnetic iron oxide nanoparticles. An alternating
magnetic field is used to excite the nanoconstructs and generate localized
heat within the tissue. The proposed model is particularly adequate for
this application, since it has a unique capability of incorporating
microvasculature configurations based on physiological data combined with
coupled capillary flow, interstitial filtration and heat transfer. A
virtual tumour model is initialized and the spatio-temporal distribution
of nanoconstructs in the vascular network is analysed. In particular, for
a reference iron oxide concentration, temperature maps of several
different hypothesized treatments are generated in the virtual tumour
model. The observations of the current study might in future guide the
design of more efficient treatments for cancer hyperthermia.