A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries

A novel method for the direct evaluation of the equimolarity
of
the compounds contained in a mixture is presented. We applied the
method toward calculating isokinetic ratios for the reaction between
the amine termini of a resin bound peptide fragment and a sulfonyl
chloride to produce equal molar mixtures of sulfonamides. The results
of this study and the application of the method to the synthesis of
two new positional scanning synthetic combinatorial libraries (PS-SCL)
are discussed.