Tcf7l2

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of insulin secretion; positive regulation of transcription by RNA polymerase II; and response to glucose. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of cellular response to growth factor stimulus; and nervous system development. Located in cytosol and nucleus. Part of catenin-TCF7L2 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Nov 2024]

该基因具备多种功能，包括DNA结合转录激活因子活性（RNA聚合酶II特异性）；RNA聚合酶II顺式调控区序列特异性DNA结合活性；以及β-连环蛋白结合活性。参与多种生理过程，诸如胰岛素分泌的正向调控；RNA聚合酶II介导的转录正向调控；以及对葡萄糖的反应。在胚胎形态发生、细胞对生长因子刺激反应的负向调控以及神经系统发育等过程中发挥上游作用或位于其中。位于细胞质和细胞核中。构成连环蛋白-TCF7L2复合体和转录调控复合体的一部分。在多个结构中表达，包括消化系统；大脑；泌尿生殖系统；感觉器官；以及皮肤。该基因的人类同源基因与乳腺癌、结直肠癌、糖尿病（多发性）、胰腺癌和前列腺癌有关。与人类TCF7L2（转录因子7样2）同源。[由基因组资源联盟提供，2024年11月]