A conserved linker between fingers 2 and 3 of KLFs is requried for full in vivo DNA binding affinity, phosphorylation and function
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A disease causing linker mutation in KLF1 alters in vivo DNA binding affinity RNAseq and ChIPseq in 14.5DPC fetal livers --------------------------------- The comparisons in cuffdiff corresponds as follows: Q1 KLF1 D45/- mRNAseq Q2 KLF1 -/- mRNAseq Q3 KLF1 +/- mRNAseq



