Global DNA Hypermethylation in Down Syndrome Placenta [Bisulfite-Seq]
收藏NIAID Data Ecosystem2026-03-10 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP017124
下载链接
链接失效反馈官方服务：
资源简介：
We have performed genome-wide DNA methylation analysis at single base resolution and gene expression analysis, resulted in hypermethylation in all autosomes in DS samples, mediated by down-regulation of all three TET family genes, and down-regulation of REST/NRSF. Genes located on chr21 were up-regulated by a median of 45% in DS compared to normal villi, while genes with promoter hypermethylation were down regulated. Overall design: DNA methylation comparison in human placenta between 6 normal and 11 Trisomy 21 samples
创建时间：
2017-09-17
