Family-wise resistance to Infectious Salmon Anemia suggests early kidney recognition protects against disease but not viral transcription

Infectious salmon anemia virus (ISAV), causative agent of infectious salmon anemia (ISA), is one of the most regulated pathogens affecting Atlantic salmon aquaculture globally. Recent investigation has suggested a linkage between the host genome and ISA resistance, identifying a potential for promoting resistance through selective breeding. Herein, we sought to explore the dynamics associated with phenotypic ISA and/or ISAV resistance using a multi-family, multi-tissue, and multi-timepoint approach to better mitigate ISA disease.