Unraveling the Genetic Architecture of Diabetic Retinopathy in South India

Sankara Nethralaya affiliates. A total of 2393 patients were recruited and included in the genetic analysis, with 1588 patients having no diabetic retinopathy (DR) serving as the controls and 805 patients with any level of DR serving as the cases. Enrolled individuals had genome-wide genotyping from DNA extracted from blood samples. In addition, whole genome sequencing (WGS) was performed on 31 members from 2 families. Clinical data, such as age, duration of diabetes, and hemoglobin A1C (HbA1c) were recorded for study participants. Diabetic retinopathy was assessed by clinical exam and/or fundus photography. The grading of diabetic retinopathy followed the International Clinical Diabetic Retinopathy Severity Scale.]]>
Inclusion Criteria: Patients with South Indian ancestry and T2D were included in the study. Exclusion Criteria:Patients with significant ocular media opacity or with ocular diseases that would impede the ability to judge the grade of Diabetic Retinopathy (DR) accurately were excluded from the study.]]>
Enrollment begin date: Sept 30, 2017 Enrollment end date: Feb 28, 2020 ]]>