Transcriptomic analysis of Tregs from RelB-dDC mice
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134779
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We report here the effect of RelB ablation in CD11c+ cells on the Treg compartment accross various organs.This mice have been backcrossed to a Foxp3 reporter mouse line to enable cell sorting of Tregs with a high purity. Interestingly, RelB ablation in DCs leads to a substantial accumulation of Tregs and these Tregs show a 'tissue Treg' signature including high expression levels of KLRG1, I1LRL1 and Gata3 when compared to Tregs of littermate control mice. Bulk RNA_Seq analysisof sort-purified Tregs
创建时间：
2019-11-12
