Transcriptional alterations due to sole ulcer revealed via RNA-seq analysis of corium tissue in lactating dairy cows (Supplemental data)

Lameness is a common condition in dairy cows, particularly during the transition period, when the weight of the udder places additional physical stress on the rear legs, and changes in immunometabolism can exert changes in the growth of hoof tissues. Sole ulcers are frequently associated with lameness in dairy cows. This study aimed to evaluate the transcriptome profile of the corium tissue of lactating dairy cows experiencing a sole ulcer condition. Hoof biopsies were performed in multiparous Holstein dairy cows selected based on their condition as clinically healthy (HC) or diagnosed with sole ulcers (SU) (n=6/group). This supplementary data contains the general information of cows enrolled in this study (Table S1), a summary of RNA concentration and quality (Table S2), as well as the summary of read counts, alignment of reads to the Bos taurus genome using HISAT2 (Table S3).