RNA Expression Data from Bovine Ovarian Granulosa Cells from High or Low Androgen-Content Follicles

Excessive androgen production is a hallmark of human and bovine ovarian disorders, and our lab has identified a naturally-occurring bovine model with excess follicular fluid androstenedione (A4) without a proportional estrogen increase. Granulosa cell populations from both the control, Low A4 follicles and the abnormal, High A4 follicles were isolated. Total RNA was extracted from those granulosa cells and submitted to the University of Nebraska Medical Center Microarray Core Facility for transcriptome quantification using Affymetrix Bovine GeneChip Gene 1.0 ST Arrays. The orignal Affymetrix .CEL files and the normalized linear expression data are included in this submission. There are two populations of granulosa cells analyzed including control granulosa cells from low androstenedione-content follicles (Low A4 GC, mean A4 = 1.9 ng/mL, n = 4) and granulosa cells from high androstenedione-content follicles (High A4 GC, mean = 356 ng/mL, n = 4).