Quantitative Proteomic Analysis of Yorkshire Pig Liver Reveals Its Response to High Altitude

In
this study, the protein profiles in the livers of Shannan Yorkshire
pigs (SNY), Linzhi Yorkshire pigs (LZY), and Jiuzhaigou Yorkshire
pigs (JZY) were comparatively analyzed using quantitative proteomics.
A total of 6804 proteins were identified, of which 6471 were quantified
and 774 differentially expressed proteins (DEPs) were screened. The
higher level of energy metabolism in LZY livers was in response to
the critical altitude environment compared to that in JZY, while the
high-altitude environment suppressed energy output in SNY livers.
Several key antioxidant enzymes were locally regulated in Yorkshire
pig liver to balance antioxidant levels in a high-altitude, low-oxygen
environment. In addition, ribosomal proteins were differentially expressed
in Yorkshire pig livers in response to different altitudinal environments.
These findings provide clues to the adaptation of the Yorkshire pig
liver to the three altitudinal environments and the molecular links
that exist between them.