Genome–wide gene expression profile of adipocytes and infiltration macrophages obtained from abdominal (visceral and subcutaneous) and peripheral (thigh) adipose depots from Normal Glucose Tolerant and Type 2 Diabetics Asian Indians. Homo sapiens

We have identified molecular-level alternations in different adipose depots (thigh, visceral and subcutaneous) of Asian Indians (both male and female) suffering from type-2 diabetes as compared to age and BMI matched normal glucose tolerant subjects by functional analysis of differentially expressed genes, and correlation of gene expression estimates with measured intermediate traits associated with T2D and its related co-morbidities (Hb1Ac, HOMA-B, HOMA-R, NEFA, Triglyceride, Total Cholesterol, HDL, LDL, VLDL, Leptin, Adiponectin, TNF-α, Serum- Creatinine, IL-6, High sensitivity - serum-creatinine (hs-CRP) and also size of adipocytes). Funding: Grant Id: 5/4/8/2012-RMC Grant title: Clinical, Biochemical and Cellular Correlates of Transcriptome of Adipose Tissue Among Type-2 Diabetics Name of the funding source: Indian Council for Medical Research Overall design: We have recruited 30 controls & 30 diabetic subjects undergoing femur bone surgery and 16 controls & 19 diabetic subjects undergoing abdominal surgery (two samples from each subject, one subcutaneous and one visceral fat biopsy were extracted). So total 130 samples were obtained and analyzed for genome –wide gene expression profile of Adipocytes and infiltration macrophages from three different depots of adipose tissue.