BindingDB Entry 50000115: Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.

Small molecule binding data for protein ALK tyrosine kinase receptor, Cyclin-dependent kinase 1/G1/S-specific cyclin-D1, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Discoidin domain-containing receptor 2, Ephrin receptor, Epidermal growth factor receptor, Fibroblast growth factor receptor, Hepatocyte growth factor receptor, Insulin receptor, Insulin-like growth factor I receptor, Leukocyte tyrosine kinase receptor, Mast/stem cell growth factor receptor Kit, Mitogen-activated protein kinase 1, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene tyrosine-protein kinase receptor Ret , Receptor tyrosine-protein kinase erbB-2, Receptor tyrosine-protein kinase erbB-4, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase Mer, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase receptor UFO, VEGF-receptor 2 and Fibroblast growth factor receptor 1, VEGF-receptor 2 and Fibroblast growth factor receptor 2, VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta), Vascular endothelial growth factor receptor 1, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot L7RSL3, P00519, P00533, P04626, P06213, P06493, P07949, P08069, P08581, P08922, P09619, P10721, P11362, P11802, P12931, P16234, P17948, P21802, P22455, P22607, P28482, P29317, P29376, P30530, P35968, Q00534, Q06418, Q12866, Q15303, Q16832, and Q9UM73