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The Senescent Methylome and its relationship with cancer, ageing, and germline genetic variation in humans

ChEBI2015-07-24 更新2026-07-12 收录

衰老表观遗传学

癌症甲基化关联

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-58035 数据链接链接失效反馈

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The Senescent Methylome and its relationship with cancer, ageing, and germline genetic variation in humans

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创建时间：

2015-07-24

衰老表观遗传学

基因表达调控

Aging is a progressive process that results in the accumulation of intra- and extracellular alterations that in turn contribute to a reduction in health. Age-related changes in DNA methylation have be

NIAID Data Ecosystem70

Genome wide DNA methylation changes with age in disease free human skeletal muscle. Homo sapiens

DNA甲基化衰老

衰老表观遗传学

A decline in skeletal muscle mass and function with aging is well recognized, but remains poorly characterized at the molecular level. Here we report for the first time a genome-wide study of DNA meth

NIAID Data Ecosystem70

DNMT1 drives 4D genome rewiring during oncogene induced senescence. DNMT1 drives 4D genome rewiring during oncogene induced senescence

衰老表观遗传学

染色体三维结构

While, transcriptional and epigenetic changes associated senescence processes are well studied, the 3D chromatin changes associated with it remains elusive. In this study, we have generated genome wid

NIAID Data Ecosystem50

Epigenetic regulation in the elderly over time. Homo sapiens

DNA甲基化动态

衰老表观遗传学

DNA methylation levels in whole blood measured over a ten years follow up in an elderly birth cohort of 86 samples Overall design: For each sample, whole blood was drawn in year 1997 and in year 2007

NIAID Data Ecosystem70

Bulk Omni-ATAC-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types. Bulk Omni-ATAC-seq in young (2 months) and aged (22-24 months) mice across 23 cell-types

衰老表观遗传学

染色质可及性分析

To understand how age rewires the chromatin accessibility landscape, we molecularly profiled 23 purified cell types from 11 tissues and organs by assessing the cumulative signature of 15-25 young and

NIAID Data Ecosystem60

The Senescent Methylome and its relationship with cancer, ageing, and germline genetic variation in humans

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