Average response indices in the in vitro DC assay, mean increase of mAb-derived different peptides and clusters in the MAPPs assay and statistical significance for aggregate preparations.

HS: aggregates generated by heat and shake stress, FT: aggregates generated by freeze and thaw stress, S: aggregates generated by shear stress, mAb1: monoclonal antibody 1, mAb2: monoclonal antibody 2, sl1: stress level 1, sl2: stress level 2, statistical test conditions: all given significance levels refer to the corresponding unstressed mAb preparation (for DC assay and MAPPs) or relate to a comparison between sl1 and sl2 (MAPPs assay only) after conducting a two-tailed paired t-test with 95% confidence; ns: not significant, >0.05;*: 0.01–0.05;**: 0.001–0.01;***: DC assay: all markers: for average response indices the mean of CD83, CD86 and CD80 was calculated; significance levels on all markers are based on average mean fluorescence intensity values of CD83, CD86 and CD80.