The top 25 dually-enriched BPMs with respect to synthetic-lethality edge distribution.

“In pathway 1” represents the fraction of pairs of genes in the first pathway of the BPM which are known to have been tested for synthetic lethality, which actually exhibited an SL relationship. Likewise, “Between pathways” and “In pathway 2” list the observed number of SL interactions over the number of known tested pairs between the two pathways and within the second pathway, respectively. The last column lists the probability of observing by chance the bias of SL edges in the BPM in favor of appearing between rather than within pathways if edges were placed independently at random between all known tested pairs.