The Keap1-Nrf2-Bach1 signaling mediates UBR7 negative regulation of HK2 to inhibit glycolysis and HCC tumorigenesis
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE173454
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We found that Keap1-Nrf2 signaling pathway mediates UBR7 to regulate HK2 expression through the modification of histone H2BK120 monoubiquitination, thereby inhibiting glycolysis and HCC tumorigenesis. The promoter regions of genes that bind to H2BK120ub in wild-type and Alb; Cre-UBR7fl/fl mouse liver primary cells were detected by ChiP-seq.
创建时间：
2022-12-10
