five

Indices of apoptosis in MPTP-intoxicated mice treated with ND-602.

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https://figshare.com/articles/dataset/_Indices_of_apoptosis_in_MPTP_intoxicated_mice_treated_with_ND_602_/1018867
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Three indices of apoptosis were measured in the SNC, activated caspase-3 immunolabeling, TUNEL labeling, and pyknotic morphology. All three indications were significantly elevated following MPTP intoxication. However, MPTP-induced apoptosis was significantly reduced ipsilateral to viral vector delivery of PGRN by ND-602, while remaining unchanged in the contralateral hemisphere. Each number represents the mean (±S.E.M., n = 5–9) number of positive cells counted across 4 coronal sections through the SNC. **sig. diff. from vehicle control, p<0.001; *p<0.05. ++sig. diff. from GFP control, p<0.001.
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2014-05-07
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