The Human Saliva Metabolome

Saliva is composed of a variety of molecules that modulate the oral cavity. It is mainly composed of water (95%) and several minor components such as electrolytes, proteins, and low molecular weight compounds. It consists of metabolites from drinks, foods, drugs, environmental contaminants, and bacterial by-products. As part of the ongoing human metabolome project, the human cerebrospinal fluid metabolome, the human serum metabolome, and recently the human urine metabolome have been characterized. Unlike urine, serum, and cerebrospinal fluid, saliva metabolomics have not shown much progress. Therefore, the present study aims at characterizing the human saliva metabolome. In an attempt to understand saliva metabolomics, we have undertaken comprehensive multi analytical tools based quantitative metabolomics. The nuclear magnetic resonance (NMR) spectroscopy data is presented in this study.