Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization

We used our novel Cherry-niche system to specifically isolate cells from the metastatic niche of 4T1 lung metastasis and compared their profile with the one obtained isolating lungs cells distal from the tumour growth Overall design: Labelling-4T1 were injected intravenuosly and lungs collected 7 days post-injection. From the dissociated tissue cells were collected via FACS and single cell RNA seqeuncing was performed