File S1 - Secondary Metabolism and Biotrophic Lifestyle in the Tomato Pathogen Cladosporium fulvum

Supporting information. Fig. S1. Domain organization of Cladosporium fulvum polyketide synthases and non-ribosomal peptide synthetases. Fig. S2. Phylogenetic analysis of Cladosporium fulvum PKS and hybrid PKS-NRPS enzymes. Fig. S3. Locus organization of polyketide synthase and hybrid genes in the Cladosporium fulvum genome. Fig. S4. Locus organization of non-ribosomal peptide synthetase genes in the Cladosporium fulvum genome. Fig. S5. Localization of secondary metabolism genes on chromosomes of Cladosporium fulvum. Fig. S6. Expression profile of Cladosporium fulvum secondary metabolism functional core genes. Fig. S7. Expression profile of genes located at the PKS6 gene locus. Fig. S8. Thin layer chromatography (TLC) analysis of Cladosporium fulvum secondary metabolites. Fig. S9. Toxicity of cladofulvin on Solanaceous plants. Table S1. Accession number of protein sequences used in phylogenetic analyses. Table S2. Oligonucleotides used in this study. Table S3. 1H and 13C NMR data for cladofulvin. Table S4. Functional annotation of Cladosporium fulvum core secondary metabolism enzymes. (PDF)