Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function [ChIP-Seq]. Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function [ChIP-Seq]

We investigated the role of Ikaros in regulatory Tcell identity and function during stimulation using RNA-seq, ATAC-seq, and H3K27ac/Foxp3/Ikzf1 ChIP-seq Overall design: We performed ATAC-seq, RNA-seq, and ChIPseq against H3K27ac, Foxp3, and Ikzf1 on mouse ex vivo Tregs isolated from spleens