AIB1D4 role in early breast cancer progression. AIB1D4 role in early breast cancer progression

We report the role of AIB1D4 in early stage breast cancer progression. Using CRISPR editing, we generated isogeneic cell lines that only express AIB1D4 and not full length AIB1 then extracted RNA for sequencing from cell lines and mamary fat pad xenografts in SCID/Beige mice. Data was aligned to Hg19 with STAR and processed with EdgeR. Overall design: Examination of RNA-seq of 4 cell lines in triplicate and three pooled tumor xenografts (MCFDCIS alone, MCFDCIS-D4 and MCFDCIS + MCFDCIS-D4) in triplicate. UPDATE: [Jan-17-2025] The titles of Samples GSM4135857-GSM4135859 were swapped with the titles of Samples GSM4135860-GSM4135862.